Background In the UK, gout management is suboptimum, with only 40% of patients
receiving urate-lowering therapy, usually without titration to achieve a target serum urate …

Physical activity (PA), including engagement in structured exercise, has a key role in the
management of hip and knee osteoarthritis (OA). However, maintaining a physically active …

To estimate the incidence, prevalence, and survival of systemic sclerosis in the United
Kingdom. We conducted a historical cohort study using data from the Clinical Practice Research …

Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population
in the UK. It is also the only arthritis that has the potential to be cured with safe, inexpensive …

Fibromyalgia is a highly heterogeneous condition, but the most common symptoms are
widespread pain, fatigue, poor sleep, and low mood. Nonpharmacological interventions are …

Importance Gout is associated with cardiovascular diseases. The temporal association
between gout flares and cardiovascular events has not been investigated. Objective To …

Gout is a common and treatable disease caused by the deposition of monosodium urate
crystals in articular and non-articular structures. Increased concentration of serum urate (…

Importance Osteoarthritis is a prevalent, debilitating, and costly chronic disease for which
recommended first-line treatment is underused. Objective To compare the effect of an internet-…

Objectives. The objectives of this study were to examine changes in the incidence and
prevalence of RA between 1990 and 2014 and to explore if there is any geographic variation in …

Objective Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse
presentations, but there are no validated classification criteria for this symptomatic arthritis. …