… & Collins, JJ Gyrase inhibitors induce an oxidative damage cellular death pathway in …
Kohanski, MA, Dwyer, DJ, Wierzbowski, J., Cottarel, G. & Collins, JJ Mistranslation of membrane …

Genetically identical cells exposed to the same environmental conditions can show significant
variation in molecular content and marked differences in phenotypic characteristics. This …

Wearable devices provide an alternative pathway to clinical diagnostics by exploiting
various physical, chemical and biological sensors to mine physiological (biophysical and/or …

BACKGROUND Small-bowel obstruction (SBO) represents as many as 16% of surgical
admissions and more than 300,000 operations annually in the United States. The optimal …

Zebrafish have become a popular organism for the study of vertebrate gene function 1 , 2 .
The virtually transparent embryos of this species, and the ability to accelerate genetic studies …

Detecting the presence of chaos in a dynamical system is an important problem that is
solved by measuring the largest Lyapunov exponent. Lyapunov exponents quantify the …

It has been proposed 1 that gene-regulatory circuits with virtually any desired property can
be constructed from networks of simple regulatory elements. These properties, which include …

Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency
of iPSC derivation and the fact that most protocols modify the genome to effect cellular …

Antibiotic mode-of-action classification is based upon drug-target interaction and whether
the resultant inhibition of cellular function is lethal to bacteria. Here we show that the three …

Background Mortality statistics are fundamental to public health decision making. Mortality
varies by time and location, and its measurement is affected by well known biases that have …