Cellular metabolism is a molecular economy that is functionally organised into supply and
demand blocks linked by metabolic products and cofactor cycles. Supply–demand analysis …

We show how metabolic regulation as commonly understood in biochemistry can be
described in terms of metabolic control analysis. The steady‐state values of the variables of …

Data on enzyme activities and kinetics have often been reported with insufficient experimental
detail to allow their repetition. This paper discusses the objectives and recommendations …

Complexity theory suggests that we see performance as an emergent property, the result of
complex interactions and relationships. This can clash, however, with what stakeholders see …

Systems biology is a vigorous and expanding discipline, in many ways a successor to
genomics and perhaps unprecedented in its combination of biology with a great many other …

The autophagic system is involved in both bulk degradation of primarily long-lived cytoplasmic
proteins as well as in selective degradation of cytoplasmic organelles. Autophagic flux is …

The Python Simulator for Cellular Systems (PySCeS) is an extendable research tool for the
numerical analysis and investigation of cellular systems. Availability: PySCeS is distributed …

Motivation: Realistic simulation of the kinetic properties of metabolic pathways requires rate
equations to be expressed in reversible form, because substrate and product elasticities are …

This paper contends that natural resource management (NRM) issues are, by their very
nature, complex and that both scientists and managers in this broad field will benefit from a …

1. Moiety‐conserved cycles are metabolic structures that interconvert different forms of a
chemical moiety (such as ATP‐ADP‐AMP, the different forms of adenylate), while the sum of …