Mediator and human disease

JM Spaeth, NH Kim, TG Boyer - Seminars in cell & developmental biology, 2011 - Elsevier
Since the identification of a metazoan counterpart to yeast Mediator nearly 15 years ago, a
convergent body of biochemical and molecular genetic studies have confirmed their structural …

Community structure and collaborative consumption: A routine activity approach

M Felson, JL Spaeth - American behavioral scientist, 1978 - journals.sagepub.com
More than a quarter of a century has passed since Hawley (1950) first presented his human
ecological theory of community structure, a theory emphasizing the structure of sustenance …

Observation of Atomlike Nitrogen in Nitrogen-Implanted Solid

…, T Pawlik, A Weidinger, M Höhne, R Alcala, JM Spaeth - Physical review …, 1996 - APS
A new paramagnetic defect in solid C 60 was produced by nitrogen implantation in solid C
60. The hyperfine splitting and the isotope effect unambiguously show that the paramagnetic …

[HTML][HTML] Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion

CL Dent, JP Spaeth, BV Jones, SM Schwartz… - The Journal of thoracic …, 2006 - Elsevier
OBJECTIVES: Neurologic deficits are common after the Norwood procedure for hypoplastic
left heart syndrome. Because of the association of deep hypothermic circulatory arrest with …

[BOOK][B] Structural analysis of point defects in solids: an introduction to multiple magnetic resonance spectroscopy

JM Spaeth, JR Niklas, RH Bartram - 2012 - books.google.com
J.-M. Spaeth JR Niklas … For the calculations necessary to describe EPR and NMR
transitions, it is useful to introduce the raising and lowering operators J and J_, respectively: …

Impact of Pdx1‐associated chromatin modifiers on islet β‐cells

JM Spaeth, EM Walker, R Stein - Diabetes, Obesity and …, 2016 - Wiley Online Library
Diabetes mellitus arises from insufficient insulin secretion from pancreatic islet β‐cells. In
type 2 diabetes ( T2D ), β‐cell dysfunction is associated with inactivation and/or loss of …

The paranasal sinuses in CT-imaging: development from birth to age 25

J Spaeth, U Krügelstein, G Schlöndorff - International journal of pediatric …, 1997 - Elsevier
Available data about the size of the different sinuses to date are derived from anatomical or
radiological studies. In order to verify or possibly correct the findings of other authors we …

[PDF][PDF] Interrupted glucagon signaling reveals hepatic α cell axis and role for L-glutamine in α cell proliferation

…, N Prasad, SN Wisniewski, A Von Deylen, J Spaeth… - Cell metabolism, 2017 - cell.com
… (J–L) Representative images of pancreatic islet a cell SLC38A5 expression are shown in
dispersed islets cultured in in (J) low AA, (K) high AA low Q, or (L) high AA media for 4 days. …

[PDF][PDF] Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity

M Turunen, JM Spaeth, S Keskitalo, MJ Park, T Kivioja… - Cell reports, 2014 - cell.com
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12
occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of …

[HTML][HTML] Machine learning optimization of candidate antibody yields highly diverse sub-nanomolar affinity antibody libraries

L Li, E Gupta, J Spaeth, L Shing, R Jaimes… - Nature …, 2023 - nature.com
Therapeutic antibodies are an important and rapidly growing drug modality. However, the
design and discovery of early-stage antibody therapeutics remain a time and cost-intensive …