User profiles for J. Kleinnijenhuis

Jan Kleinnijenhuis

Professor of Communication Science, Vrije Universiteit Amsterdam
Verified email at vu.nl
Cited by 5341

[HTML][HTML] Innate Immune Recognition of Mycobacterium tuberculosis

J Kleinnijenhuis, M Oosting, LAB Joosten… - Journal of Immunology …, 2011 - hindawi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

J Kleinnijenhuis, J Quintin, F Preijers… - Proceedings of the …, 2012 - National Acad Sciences
Adaptive features of innate immunity, recently described as “trained immunity,” have been
documented in plants, invertebrate animals, and mice, but not yet in humans. Here we show …

Trained immunity: consequences for the heterologous effects of BCG vaccination

J Kleinnijenhuis, R Van Crevel… - Transactions of the …, 2015 - academic.oup.com
A growing body of evidence from epidemiologic and immunologic studies have shown that
in addition to target disease-specific effects, vaccines have heterologous effects towards …

The role of autophagy in host defence against Mycobacterium tuberculosis infection

M Songane, J Kleinnijenhuis, MG Netea, R van Crevel - Tuberculosis, 2012 - Elsevier
Autophagy is a vital homeostatic process triggered by starvation and other cellular stresses,
in which cytoplasmatic cargo is targeted for degradation in specialized structures termed …

Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity

J Kleinnijenhuis, J Quintin, F Preijers, CS Benn… - Journal of innate …, 2014 - karger.com
We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy
volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine …

[BOOK][B] Doing research in political science: An introduction to comparative methods and statistics

P Pennings, H Keman, J Kleinnijenhuis - 2005 - books.google.com
This is an immensely helpful book for students starting their own research... an excellent
introduction to the comparative method giving an authoritative overview over the research …

[PDF][PDF] Immunometabolic pathways in BCG-induced trained immunity

…, C Palma, F Rodrigues, R Silvestre, J Kleinnijenhuis… - Cell reports, 2016 - cell.com
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated
infections are thought to be mediated by long-term metabolic changes and chromatin …

BCG-induced trained immunity in NK cells: role for non-specific protection to infection

J Kleinnijenhuis, J Quintin, F Preijers, LAB Joosten… - Clinical …, 2014 - Elsevier
Adaptive features of innate immunity, also termed ‘trained immunity’, have recently been
shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity …

News selection criteria in the digital age: Professional norms versus online audience metrics

…, J Kleinnijenhuis, N Ruigrok, J Schaper - …, 2016 - journals.sagepub.com
On newspaper websites, journalists can observe the preferences of the audience in
unprecedented detail and for low costs, based on the audience clicks (ie page views) for specific …

Strategic framing in the BP crisis: A semantic network analysis of associative frames

F Schultz, J Kleinnijenhuis, D Oegema, S Utz… - Public Relations …, 2012 - Elsevier
This paper contributes to the analysis of the interplay of public relations and news in crisis
situations, and the conceptualization of strategic framing by introducing the idea of associative …