We have not yet reached a point at which routine sequencing of large numbers of whole
eukaryotic genomes is feasible, and so it is often necessary to select genomic regions of interest …

The human X chromosome has a unique biology that was shaped by its evolution as the sex
chromosome shared by males and females. We have determined 99.3% of the euchromatic …

X-linked lymphoproliferative syndrome (XLP or Duncan disease) is characterized by extreme
sensitivity to Epstein-Barr virus (EBV), resulting in a complex phenotype manifested by …

Previous studies have failed to identify mutations in the Wilson’s disease gene ATP7B in a
significant number of clinically diagnosed cases. This has led to concerns about genetic …

Application of a novel vectorette PCR approach to defining intron-exon boundaries has
permitted completion of analysis of the exon structure of the largest and most complex known …

Studies have revealed that organizational commitment is often managed through symbolism.
This paper focuses upon how time is used in an organizational context, symbolically and …

Gene-regulatory network analysis is a powerful approach to elucidate the molecular
processes and pathways underlying complex disease. Here we employ systems genetics …

Purpose Several groups and resources provide information that pertains to the validity of
gene–disease relationships used in genomic medicine and research; however, universal …

Defects in USH2A cause both isolated retinal disease and Usher syndrome (ie, retinal
disease and deafness). To gain insights into isolated/nonsyndromic USH2A retinopathy, we …

DNA methylation is one of the most studied epigenetic marks in the human genome, with the
result that the desire to map the human methylome has driven the development of several …